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A Handbook for DNA-Encoded Chemistry: Theory and Applications for Exploring Chemical Space and Drug

ookName:A Handbook for DNA-Encoded Chemistry: Theory and Applications for Exploring Chemical Space and Drug Discovery
Author:Robert A. Goodnow Jr.<

編號:1171776出版時間:2014格式:pdf

出版社:Wiley作者:Robert A. Goodnow Jr.

熱度:頁數:480ISBN:1118487680,9781118487686

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  • A Handbook for DNA-Encoded Chemistry: Theory and Applications for Exploring Chemical Space and Drug介紹

    BookName:A Handbook for DNA-Encoded Chemistry: Theory and Applications for Exploring Chemical Space and Drug Discovery
    Author:Robert A. Goodnow Jr.
    Publisher:Wiley

    This book comprehensively describes the development and practice of DNA-encoded library synthesis technology. Together, the chapters detail an approach to drug discovery that offers an attractive addition to the portfolio of existing hit generation technologies such as high-throughput screening, structure-based drug discovery and fragment-based screening. The book:

    • Provides a valuable guide for understanding and applying DNA-encoded combinatorial chemistry
    • Helps chemists generate and screen novel chemical libraries of large size and quality
    • Bridges interdisciplinary areas of DNA-encoded combinatorial chemistry – synthetic and analytical chemistry, molecular biology, informatics, and biochemistry
    • Shows medicinal and pharmaceutical chemists how to efficiently broaden available “chemical space” for drug discovery
    • Provides expert and up-to-date summary of reported literature for DNA-encoded and DNA-directed chemistry technology and methods

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