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Enzyme Kinetics in Drug Metabolism: Fundamentals and Applications

ookName:Enzyme Kinetics in Drug Metabolism: Fundamentals and Applications
Author:Swati Nagar, Upendra A. Argikar, Donald J. Tweedie (eds.)
Publi

編號:1162434出版時間:2014格式:pdf

出版社:Humana Press作者:Swati Nagar, Upendra A. Argikar, Donald J. Tweedie (eds.)

熱度:頁數:538ISBN:978-1-62703-757-0,978-1-62703-758-7

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  • Enzyme Kinetics in Drug Metabolism: Fundamentals and Applications介紹

    BookName:Enzyme Kinetics in Drug Metabolism: Fundamentals and Applications
    Author:Swati Nagar, Upendra A. Argikar, Donald J. Tweedie (eds.)
    Publisher:Humana Press
    This book is divided into ?ve parts. Part I provides the fundamental principles of enzyme kinetics. How are these parameters derived? While these are fundamental concepts dealt with in other texts, what do they really mean from a drug metabolism and transport perspective? This book aims at answering this question. Part II of the book focuses on the kinetics of oxidative and conjugative drug metabolizing enzymes and drug transporters. Part III considers some modeling approaches for both drug metabolizing enzymes and transporters. Understanding of variability—intrinsic and extrinsic—is dealt with in Part IV and is considered crucial from “design of experiments” to “interpretation of results.” Finally in Part V, case studies provide real-life examples, conversations between supervisor and scientist, and current outlooks, which provide opportunities from which we can all learn.

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